The ABCD1 gene
Sequence and organization of the ABCD1 gene
Genetic linkage to glucose-6-phosphate dehydrogenase (G6PD) placed the ALD locus at the end of the long arm of the X chromosome, Xq28. In 1993, the ABCD1 gene was identified using positional cloning strategies (Mosser et al., 1993). The gene is 19.9 kb, consist of 10 exons, and encodes for a protein of 745 amino acids. The ALD protein (ALDP, or ABCD1) belongs to the human protein family of ATP-binding cassette (ABC) transporters. The ALD protein belongs to subfamily D, member 1 (ABCD1).
Last modified | 2024-06-25