The purpose of the adrenoleukodystrophy website is to provide general educational information about ALD. We aim to cover as many aspects of ALD as possible. This database and the information contained herein is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please refrain from using our website for the diagnosis or treatment of ALD. While we offer information, always consult your professional healthcare provider for specific disease-related questions or concerns.
Contributors are responsible for the reliability of unreviewed data published on this website. Although considerable effort has been made to ensure the ABCD1 Variant Database’s high quality, the laboratories/investigators identifying these variants provide no warranty, expressed or implied, regarding the accuracy of the information or its suitability for any specific purpose. Users should exercise caution for several reasons:
- A phenotype/genotype correlation in ALD does not exist. Predicting disease course based on a genetic variant, even within individual families, is not possible.
- The ‘variant’ may be a technical artifact.
- For many variants of uncertain significance (VUS), experimental proof demonstrating that the variant is not pathogenic — or benign — is lacking.
- Due to the high percentage of unique variants in the ABCD1 gene, the pathogenicity of many variants has not been confirmed by independent findings.
Unpublished variants may not be used for publication purposes without prior approval from the database editor and the laboratories/investigators that identified and reported these variants.
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Last modified | 2023-11-29