X-linked adrenoleukodystrophy (ALD) is the most common leukodystrophy with a birth incidence of 1 in 15.000 newborns. It is a progressive, “inborn error of metabolism” that affects brain, spinal cord, peripheral nerves, adrenal cortex and testis. ALD is caused by mutations in the ABCD1 gene. More than 800 unique mutations have been identified. For a comprehensive summary, please visit the Facts on ALD page.

Mutations & Biochemistry

A catalogue of the >775 unique mutations and variations in the ABCD1 gene; info on biochemistry, the ALD gene, etc.

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Clinical & Diagnosis

Read posts on different clinical presentations of ALD in males and females, newborn screening and watch educational videos and webinars.

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Treatment options

Read about successful and unsuccessful treatment options.

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Hugo Moser

Hugo Moser, Neurologist World-Renowned for his Relentless Fight Against ALD Researcher Leaves Legacy of Hope for Families with ALD (October 4, 1924 – January 20, 2007) Baltimore, MD – Hugo...

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On Twitter

Follow the ALD database on twitter to keep up-to-date with the latest news and other interesting facts related to ALD. Or read our latest tweets below.

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